What is the pathogenesis of diabetic nephropathy

The pathogenesis of diabetic nephropathy is very complicated, realizing it can be beneficial for people to keep their eyes on precautions and nursing in the daily life. Next we will introduce three main pathogenesis for people to refer to.

Genetic background. Diabetes is a polygenetic disease, no matter type 1 diabetes or type 2, there is a high relationship with individual’s genetic background whether people will get diabetic nephropathy or not. Someone who has blood glucose and blood pressure under control still suffer from diabetic nephropathy, while someone even though not control blood glucose and blood pressure well, they never experience diabetic nephropathy, which implies that individual’s different genetic backgrounds have different susceptibility to diabetic nephropathy. The incidence of diabetic nephropathy also depends on racial and ethnic, for instance, Asian people have a higher incidence of kidney disease than Caucasians.
1. Hemodynamic changes. Hemodynamic has already changed at the early stage of diabetic nephropathy, it plays an important role in the formation of diabetic nephropathy. Hemodynamic changes are mainly reflected in high perfusion, high filtration and high pressure within the glomerulus, all of these factors make glomerular work under the higher load, if this situation lasts long, glomerular will become fat, the open areas of vasoganglion will increase, basement membrane of blood vessel will become thicken and permeability increase, and then it will proceed to proteinuria and glomerular sclerosis which eventually promote the formation of diabetic nephropathy.
2. Metabolic disorder and insulin resistance. The most basic pathological change of diabetes is sugar metabolic problems, in this situation sugar in the body is higher than the normal range. Unfortunately, blood sugar and high glucose in the blood is toxic, called the“toxic sugar”, which is mainly because too much glucose may activate some substance which is harmful to kidney, it is thus that cause the diabetic nephropathy.
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