Which factors are associated with prognosis of chronic nephritis

Chronic glomerulonephritis will develop into renal failure after years unhealed, but the rate of progress come different in different people. We can not cure this disease fundamentally at present, while if we have the ability to prolong their renal function for years or decades, provide their chances to live and work normally, it is not only highly beneficial for patients and their families, but also for the society. Accordingly, those factors connected with progressing speed turn into focus to people. Here are some factors that already known.

1. Pathological factors. Different pathological change, different prognosis. For example, compared to severe mesangial proliferative glomerulonephritis and membrano proliferative glomerulonephritis, prognosis of simply mild mesangial proliferative glomerulonephritis is better. 50% Membrano proliferative glomerulonephritis develop renal failure in 10 years, chronic renal disease generally progress slowly and have good prognosis, few develop renal failure in 5 years, while focal segmental glomerulosclerosis has poor prognosis and usually develop into uremia in 10 to 20 years. In addition, other pathological factors affecting prognosis are: the crescent, the poorer prognosis is; patients with obvious or severe lesions on vessels inside kidneys like fibrinoid necrosis of small arteries have poor prognosis; patients with interstitial fibrosis and tubular atrophy have poor prognosis.
2. Clinical factors. ① patients have history of hemolytic streptococcus infection before have better prognosis;② who do not have other clinical symptoms except proteinuria or hematuria have better prognosis; ③ who have severe high blood pressure or high blood pressure progressing rapidly have poor prognosis, while patients can control the high blood pressure by medicines have better prognosis; ④ patients with little urine protein volume after treatment have better prognosis than those who have more or normal urine protein volume; ⑤ who with obvious anemia and edema have poor prognosis.
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