The common causes of chronic interstitial nephritis is drug or renal toxic substances. Taking these drugs with high-dose in a short term can cause acute tubular interstitial nephritis which has obvious symptoms, and patients who develop this disease can seize the best opportunity to see doctor. While taking some drugs with small doses for a long time like abusing painkillers, long-term application of ring spore element, methotrexate, non-steroidal anti-inflammatory drugs is prone to develop chronic interstitial. Other common causes are chronic pyelonephritis, urinary tract obstruction and uric acid nephropathy caused by high uric acid, etc. Early pathological performance of primary chronic interstitial nephritis is given priority to the infiltration of interstitial inflammatory and without glomerular lesions, so patients won’t appear the clinical manifestations of glomerulonephritis like edema, proteinuria and hypertension. It is because of no obvious symptoms that patients are more likely to miss the best time to see doctors.
With the progress of pathological changes, renal tubules which is buried in renal interstitial will have varying degrees of compensatory expansion and contraction and a tubular dysfunction, which is characterized by increased nocturia, renal tubular acidosis and renal glycosuria,etc. It is very likely to stop the progression of lesions if patients go to see doctor timely and avoid contacting the harmful drugs at this stage. While when disease develop into the end stage, interstitial fibrosis in great quantities and involving the glomerular around, which can cause secondary glomerular sclerosis, proteinuria, hypertension and edema. If patients see the doctor until this stage, only dialysis can work because of its severe condition of renal failure which is irreversible.
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