1. The main reason of uremia patients inappetence is the damage of kidney function due to pathological changes of kidney. When kidney loss its function, the metabolites and toxins accumulated in body can not be discharged in time, which will lead to disorder of digestive system or nervous system.
2. As the kidney function decreasing, some of the substances produced by digestive system can not be discharged through bloodstream, which will accumulate in gut. The increase of urea in these substances is the most obvious, the urease produced by intestinal bacteria can resolve the urea into ammonia, the increase of ammonia will stimulate gastrointestinal mucosa leading to multiple gastrointestinal superficial ulcer, which will result in the patients feeling sick.
3. Excess metabolites and toxins in the body will invade into brain tissue through hemato encephalic barrier, which stimulate brain centres that control nausea and vomiting, leading to loss of appetite.
When you have long-standing symptoms such as inappetence, anorexia, sick, emesis and diarrhea, please don’t ignore these conditions, except for checking the digestive system, it’s important to do a kidney function test.
Read more please refer to "Can I Stop Dialysis"
