In clinical, patient with
nephritic syndrome usually associated with
hyperlipemia, why dose it happen? It should be started from the manifestation of
nephritic syndrome. The performances of the nephrotic syndrome are mainly
include a large amount of proteinuria(≥3.5g/d), hypoproteinemia(≤30g/L),
hyperlipemia and edema.
The mechanism of nephrotic syndrome hyperlipidemia is related to the increase
of liver synthetic lipoproteins and the reduce of lipoprotein decomposition. The
excessive protein to nephritic syndrome patients will result in a decrease of
albumin in plasma. Liver is the main place to plasma protein synthesis, in order
to replenish the lost protein, the liver will compound large amounts of protein,
in this progress, lots of cholesterol, triglyceride and lipoprotein will be
compounded as well, at the moment, the change of lipid enzymes regulating
function and lipoprotein activity will lead to obstacles of lipid removal.
the lipid metabolism disorders of the patients with nephrotic syndrome can be
shown as the increase of all kinds of lipoprotein in plasma components, total
cholesterol, low density lipoprotein. Hyperlipemia is caused by the obesity,
diabetes and excess alcohol due to the excessive VLDL(very low density
lipoprotein) and VLDL transform into LDL(low density lipoprotein). Nephrotic
syndrome can lead to excess liver VLDL and the disorder of LDL.
Besides, remove obstacles may also result from the decrease in the number of
LDL receptor, which can be caused by diet factor.
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